Intellectual Property Office
Non-Confidential Disclosures
“Adaptive Optimal Control of Glucose Level in Type I Diabetes Patients”
PSU Software Disclosure Number 2006-S104
Field of the Invention:
Psychophysiological and Medical Signal Analysis
Inventors:
Peter C.M. Molenaar, Ph.D., Jan S. Ulbrecht, M.D., Michael J. Rovine, Ph.D., Carol Hancock Gold, Ph.D.
Background:
Type I diabetes mellitus is characterized by the inability of the body to regulate blood glucose levels. Since the 1970s extensive research has been carried out to develop an "artificial endocrine pancreas", i.e., a control algorithm capable of maintaining normoglycemia over extended periods of time in diabetic patients. These control algorithms are based on mathematical models of the glucoregulatory system which do not adequately describe the glucose level behavior of individual patients. Moreover, the control algorithms now available are not fully adaptive and therefore cannot accommodate patient-specific aspects of the glucoregulatory system.
Invention description:
We have developed a new data-driven control algorithm for improved control of glucose levels in type I diabetes patients. Our approach is person-specific in that each patient is modeled individually. This will limit as a source of error inter-individual heterogeneity. Moreover, our modeling approach removes intra-individual heterogeneity in time (nonstationarity) as a source of error. It is likely that more complex modes of insulin administration will emerge from this modeling effort than the simple basal, bolus and square wave bolus currently used in insulin pumps.
Advantages:
- Data-driven patient-specific modeling
- Adaptive optimization of insulin dosage in real time
- Feedforward control option
- Easily extendable with biophysical theoretical models
- Potentially Medicare cost-reducing while optimizing quality of life
Contact:
James F. Kolonay, Ph.D.
Technology Licensing Officer
Intellectual Property Office
113 Technology Center
The Pennsylvania State University
University Park, PA 16802-7000
Phone: (814) 863-7070
Fax: (814) 865-3591
E-mail: jfk11@psu.edu
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