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Healthy males sought for study of omega-3 fatty acids and inflammation

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Research Participant Criteria

To be eligible for this study, you must meet the following criteria:

  • Gender: Male
  • Age: 20 - 45 Years
  • Average weight (20-30 BMI)
  • Generally healthy
  • No tobacco use
  • Not taking anti-inflammatory medications or omega-3 supplements (fish or flaxseed oil)
  • Consume <2 servings of high omega-3 fish per week
Exclusion Criteria

You are not eligible if any of the following applies to you:

  • Female
  • Allergy to fish
  • Use of glucose-lowering, blood pressure lowering, or blood thinning medications
  • Unwilling to stop vitamins, minerals, or cholesterol-lowering supplements
  • History of diabetes, heart disease, or vasovagal reactions (unprovoked fainting)

Research Study Details

Effects of a prescription omega-3 fatty acid concentrate in a placebo-controlled trial of human endotoxemia

Male participants are being sought for a study examining the role of omega-3 fatty acids in reducing the inflammatory response to a non-living bacterial agent. The Pronova Study is looking for healthy, non-smoking, normal weight males aged 20-45 years with no history of diabetes or heart disease. Subjects should not be taking anti-inflammatory medications, omega-3 fatty acid supplements, or consume 2 or more servings of high omega-3 fish per week. Participants will be required to consume capsules daily for two 8 week periods and have a 10 hour stay at the CRC at the end of each period. The total duration of the study is 24 or more weeks. If you fit these criteria and would like to participate in this study, please call 1-814-863-8622 or email PronovaStudy@gmail.com. Mention the Pronova Study and leave your name and a contact number. Subjects will receive blood test results and compensation of $300. This study is being conducted by Dr. Ann Skulas-Ray, Dr. Gordon Jensen, and Dr. Penny Kris-Etherton at Penn State University.

The purpose of this study is to examine the effect of omega-3 fatty acids on inflammatory responses. We are looking for healthy male volunteers between the ages of 20 and 45, with a BMI between 20 and 30 (you can check your BMI at http://www.nhlbisupport.com/bmi/).

 

Participants will be required to take 4 capsules each day for two 8-12 week periods.  These capsules will contain omega-3 fatty acids or olive oil. At the end of each supplementation period, there will be a day of testing that includes a mild inflammatory challenge.  Each day of testing will consist of an approximately 10 hour stay at the Clinical Research Center on the Penn State campus (e.g. 6:30 AM – 4:30 PM). You will have an intravenous catheter (IV) inserted into each arm by trained nurses. You will be provided with food (breakfast, lunch, dinner, and snacks) during the visit. There will be an 8 week washout in between the two supplementation periods and at least 4 months in between each of the two test days.

 

The total duration of the study will be 24 or more weeks but you may travel during the study. The compensation for this study is $300 and is considered income.  At the end of the study you will also receive the results of lab tests. 

 

If you fit these criteria and would like to participate in this study, please call 1-814-863-8622 or email PronovaStudy@gmail.com.  Mention the Pronova Study and leave your name and a contact number.

Study Dates, Times and Location

Study Available by Appointment?: Yes
Location: Clinical Research Center, Noll Laboratory
Approximate Participant Study Length: 24 Weeks

There will be two 8-12 week supplementation periods with an 8 week washout period in between, for a total time commitment of 24 or more weeks.

You will be allowed to travel during the study.

Compensation: $300

Contact Information

Chesney Richter or Ann Skulas-Ray
814-863-8622
PronovaStudy@gmail.com

This study has been approved by a Penn State Institutional Review Board (IRB). IRB Approval Number 41589