The purpose of this Funding Opportunity Announcement is to continue support for an ongoing research program that has accumulated longitudinal structural and functional brain imaging data, and neurocognitive assessments, concurrent with extensive clinical data in an actively followed cohort comprising four groups: HIV infection, alcoholism, HIV with alcoholism, and unaffected controls. The National Institute on Alcohol Abuse and Alcoholism invites cooperative agreement applications to evaluate the cumulative and progressive effects of combined HIV infection and alcohol abuse in patient populations that are growing older and living well longer. This project must address several questions of current interest, including, but not limited to coinfection with the Hepatitis C virus, involvement of peripheral neuropathy in frailty, potential neurotoxic effects of antiretroviral medications, and interactive effects with advancing age on sensory and motor functioning. Clinical research knowledge that would be gained from this project could position "translational" efforts in the development of better and more focused treatments for observed comorbid neurological, cognitive, and motor deficits, which may also be relevant to other disease-affected aging populations. This project must directly address the NIH Office of AIDS Research priority for understanding "HIV-associated comorbidities, coinfections, and complications including: addressing the impact of HIV-associated comorbidities, including tuberculosis, malignancies; cardiovascular, neurological, and metabolic complications; and premature aging associated with long-term HIV disease and antiretroviral therapy." These efforts are necessary as the comorbidity of HIV infection with alcohol abuse is substantial and continues to remain a public health issue.
For more information visit: https://grants.nih.gov/grants/guide/rfa-files/RFA-AA-18-011.html
Cover Page must include:
- Descriptive title of proposed activity
- Name(s), address(es), and telephone number(s) of the PD(s)/PI(s)
- Names of other key personnel
- Participating institution(s)
2 page summary to include:
- How the on-going program leads to the development or extension the project's major goals and objectives, and how it complements or enhance existing studies. Explain how the proposed project will provide new and relevant scientific knowledge on existing patient cohorts that were not previously available. Critically evaluate existing knowledge and approaches that have been or are being applied in the area and specifically describe how the proposed studies will advance the field.
Questions concerning the limited submissions process may be submitted to limitedsubs@psu.edu.